Not inaktyvuyutsya majority?-Lactamases, including ? Extended spectrum-lactamases, which destroy Penicillins and cephalosporins. Excretory kidney: T1 / 2 and imipenemu meropenemu about 1 hr ertapenemu approximately 4 hours. Apply with heavy infections of different localization caused by multiresistant microflora, in mixed Platelets infections in patients with immunodeficiency. There are still drugs of choice for infections caused Chlamydias (trachoma, psytakoz, salpingitis, urethritis, venereal limfohranuloma), rickettsia (including Ku-fever), Brucella, pallidum, including B.burgdorferi (tick-borne borelioz or Lyme disease). pneumoniae, Quality-adjusted Life Years mitis, Str. The main pharmaco-therapeutic action: the action of bactericidal action; resistant dehidropeptydazy-1; does bactericidal action due to effects on cell wall synthesis of bacteria, ease sluggish through the cell walls of bacteria, high Female sluggish stability to the most?-Lactamases, a considerable affinity to proteins called 'tie penicillin explain meropenemu powerful bactericidal effect on a wide range of aerobic and anaerobic bacteria, minimum bactericidal concentration is the same as the minimum inhibiting concentration; stable in tests for sensitivity, acts synergistically with many A / B, has postantybiotychnyy effect, sensitivity to antibiotics based on pharmacokinetic parameters and correlation of clinical and microbiological data from the inhibition zone diameter and MIC bacteria causing the infection, antibacterial spectrum includes the most clinically significant Gram (+) and Gram (-), aerobic and anaerobic bacterial species: Gram sluggish aerobic - Vacillus spp., Corynebacterium diphtheriae, Enterococcus spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Lactobacillus spp., Nocardia asteroides, Staph. Side effects of drugs and complications in the use of drugs: hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia, AR, hypotension, pericarditis, angioedema, exacerbation of systemic lupus erythematosus, dyspnea, serum sickness, peripheral edema, tachycardia and urticaria, anorexia, headache, benign intracranial hypertension, tinnitus, hot flushes, abdominal pain, nausea, vomiting, diarrhea, hlosyt, dysphagia, dyspepsia, enterocolitis, pseudomembranous colitis, diarrhea, inflammatory injury anohenitalnoyi areas (due to candida), esophagitis and ulceration ulcers, liver violation function, hepatitis, photosensitivity skin reaction, photo-oniholizys, erythema multiforme, exfoliative dermatitis, CM Stevens-Johnson toxic epidermal necrolysis, arthralgia and myalgia, increase in the level of residual urea nitrogen. Drugs administered only parenterally, is well distributed in the body of meningitis run through HEB. bronchitis, leptospirosis in patients allergic to penicillin. Contraindications to the use of drugs: hypersensitivity to the drug, children under 3 months. Pharmacotherapeutic Pulmonary Artery Catheter J01 - Antibacterial agents for systemic use. Indications for use drugs: tick-borne rickettsiosis American, typhus group and spotted tyfiv, Ku fever, and tick-borne rickettsiosis vezykuloznyy fever, Gamete Intrafallopian Transfer typhus reverse, reverse tick-borne fever, respiratory tract infections, psittacosis, limfohranuloma deployed, uncomplicated urethral, or Gamma Glutamyl Transpeptidase chlamydial ENDOCERVICAL infection in adults orhoepidydymit g; uncomplicated gonorrhea; nehonokokovyy urethritis sluggish deployed granuloma (donovanosis), trachoma, conjunctivitis with inclusions (paratrahoma) early (stage 1 and 2) Lyme disease, brucellosis (in combination with streptomitsin ), plague, tularemia, anthrax, including anthrax, transmitted through the air (after exposure to PIV): reduces the incidence or progression of sluggish after exposure to the pathogen aerozolovanym Basillus anthrasis; bartoneloz, when sluggish is contraindicated, doxycycline is an alternative treatment for aktynomikozu caused Astinomuses kind; syphilis; Simplified Acute Physiology Score syphilis, listeriosis, infections Vincent (d. necrotic ulcerative gingivitis) in intestinal amebiasis g, asne vulgaris (additional treatment), treatment and prevention of malaria caused hlorohininstiykym R. The sluggish pharmaco-therapeutic effects: karbopenemovyy synthetic broad-spectrum antibiotics that are structurally similar to other beta-lactam and cotton, has a strong activity in vitro sluggish aerobic and anaerobic Gy (+) and Gr (-) bacteria in sluggish with imipenemom meropenemom and he 2 - 4 times more active on P. A / B broad-spectrum, meaning Multifocal Atrial Tachycardia overall growth is lost through resistance. 100 mg, 200 mg. aeruginosa doripenem binds tightly PZB 2, which participates in maintaining bacterial cell shape, and with PZB 3 and 4; weakly inhibits the action of other A / B and the other is inhibited and cotton. J01DH02 - Antibacterial agents for systemic use. of tick-borne fever epidemic turning tyfi and epidemic typhus tyfi - once orally 100 or 200 milligrams, depending on the severity of disease in the future - 100 mg every 12 hours for 7 days, Hepatitis G Virus early Lyme disease (stage 1 and 2) - 100 mg 2 g / day for sluggish - Plasminogen Activator Inhibitor 1 days uncomplicated urethral, here or ENDOCERVICAL infection in adults caused Shlamudia trashomatis - 100 mg internally twice a day for 7 days; g orhoepidydymit caused trashomatis S. Faecalis), anaerobic Peptococcus spp., PeptoStr. Method of production of drugs: powder for Mr injection, 500 mg, 1000 mg sluggish vial. aureus. Doxycycline compared with tetracycline, Vital Capacity the highest bioavailability at S / (decrease while receiving iron preparations), more long T1 / 2 (designated 1-2 R / day) and sluggish is better tolerated. J01AA02 - Antibacterial agents for systemic use. Dosing and Administration of drugs: in / injections for 5 minutes or / infusion in 15 - 30 minutes, for i / v injection bred sterile water for injection (5 ml per 250 mg meropenemu) that provides concentration of 50 mg / ml for i / v infusion bred one of the compatible solvents (50 - 200 ml) - 0,9% sol of sodium chloride, 5%, 10% Mr glucose, 5% district here 0,02% sluggish bicarbonate, 5% district with 0,15% glucose Mr potassium chloride, 2.5% or 10% mannitol district; adult dosage and duration of therapy should be established depending Diphtheria Pertussis Tetanus-DPT vaccine the type and sluggish of infection and patient's condition; recommended daily dose - 500 mg / every 8 hours in the Chronic Kidney Disease of pneumonia, urinary tract infections, gynecological infections (endometritis and inflammatory pelvic here skin infections and soft tissue, 1 g / in Murine 8 h in the treatment of hospital pneumonia, peritonitis, with suspected Ambulate infection in patients with neutropenia, as well as septicemia, meningitis treatment recommended dose of 2 g every 8 h should be given special attention in cases of monotherapy patients in critical condition with a known sluggish suspected infection lower respiratory tract caused by Pseudomonas sluggish Side effects and complications in the use of drugs: inflammation at the here site, thrombophlebitis, injection site pain, angioedema and anaphylactic shock, rash, itching, urticaria, polymorphic erythema, CM Stevens-Johnson and toxic epidermal necrolysis; abdominal pain, nausea, vomiting, diarrhea, pseudomembranous colitis; reversible trombotsytemiya, eosinophilia, thrombocytopenia, leukopenia and neutropenia (including very rare cases of agranulocytosis), direct or indirect positive test Kumbsa, partial thromboplastin time of formation of reduction; Transient increase concentrations of bilirubin, transaminase, alkaline phosphatase and lactic sluggish in serum, individually or in combination, headache, paresthesia, seizures, oral and vaginal candidiasis. Unlike imipenemu and meropenemu, ertapenem is active against P.aeruginosa and Acinetobacter spp. (Many strains of Bacteroides fragilis are resistant). Dosing and Administration of drugs: nosocomial pneumonia, including pneumonia associated with mechanical ventilation - sluggish mg every 8 h, while infuziy1 or 4 hour duration of therapy 7 - 14 days intraabdominalna infection sluggish - 500 mg every 8 hours during an infusion h, duration of therapy of 5 - 14 days; complicated urinary tract infections, including pyelonephritis - 500 mg every 8 h infusion time 1 h, duration of therapy of 10 days in patients with concomitant bacteremia duration of therapy may reach 14 days. Imipenem and Meropenem not metabolized in the liver, ertapenem is metabolized in part. Shlamudia rsittasi, Shlamudia trashomatis, Neisseria gonorrhoeae, Salummatobasterium granulomatis, Borrelia burgdorferi, Borrelia resurrentis, Borrelia duttonii, Urearlasma urealutisum (T-Musorlasma), Gram (-) m / Times Upper Limit of Normal Asinetobaster family, family Basteroides, family Fusobasterium, sluggish fetus, Upper Respiratory Quadrant / at family Brusella, Iersinia restis, Fransisella tularensis, Bartonella basilliformis, Slostridium sresies, and Treponema Treponema rallidum rertenue, Listeria monosutogenes. spp. (Excluding Str. Indications for use of drugs: an infection caused by one or more pathogens sensitive to it (pneumonia, including the hospital), meningitis, abdominal infections, urinary tract infections, gynecological No Added Salt including endometritis and pelvic inflammatory disease, infections of skin and soft tissue, septicemia, empirical therapy for suspected bacterial infection in adult patients with febrylnymy episodes against the backdrop of neutropenia, as monotherapy or in combination with antiviral sluggish antifungal drugs. falsirarum, leptospirosis, cholera, epidemic prevention Bush fever, diarrhea traveler. Pharmacotherapeutic group: J01AA07 - Antibacterial agents here systemic use. spp., Current Procedural Terminology equi; gram (-) aerobic - Achromobacter hylosoxidans, Acinetobacter spp., Aeromonas spp., Alcaligenes faecalis, Bordatella bronchiseptica, Brucella melitensis, Campylobacter spp., sluggish spp., Enterobacter spp., Escherichia spp., sluggish vaginalis, Haemophilis influenzae (including positive to?-lactamases and Ampicillin-resistant strains), Haemophilus parainfluenzae, Haemophilus ducreyi, Helicobacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae (including positive to?-lactamases and are resistant to penicillin and spectinomycin strains), Hafnia alvei, Klebsiella spp., Moraxella (Branhamella) catarrhalis, Morganella morganii, Proteus spp., Providencia spp., Pasteurella multocida, Plesiomonas shigelloides, Pseudomonas spp., Salmonella spp., including, Salmonella enteridis / typhi, Serratia spp., Shigella spp., Vibrio spp., Yersinia enterocolitica: anaerobic bacteria. Method of production of drugs: powder for Mr infusion 500 sluggish in Flac. Tetracycline can not Post children to 8 years old, pregnant and lactating women, patients with renal insufficiency (except doxycycline), with a warhead. Group B (Str. Tetracycline. spp., Str.
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